Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus. However, limitations of multiple dosing and risk of triggering gastrointestinal symptoms make its dose optimization difficult. The present study was designed to develop an oral sustained release metformin hydrochloride tablet by using synthetic hydrophilic Edragit RLPO alone or in combination with hydrophobic natural polymers Gum copal and Gum damar, as rate controlling factor. The in-vitro dissolution study was carried out using USP 22 apparatus II, paddle method. The drug release study revealed that Edragit RLPO alone was able to sustain the drug release only for 8 h (93.697% �± 1.18% release). Combining Edragit with Gum copal and Gum damar sustained the drug release for 12 h (93.517 % �± 0.60% and 89.710 % �± 0.42 % release respectively). Kinetic modeling of in-vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport. Applying Korsmeyer equation to in-vitro drug release data indicated that diffusion along with erosion could be the mechanism of drug release.
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